Mitragyna speciosa Health effects and herbal facts

Mitragyna speciosa is a tropical deciduous and evergreen tree in the coffee family native to Southeast Asia in the Indochina and Malesia floristic regions. Its leaves are used for medicinal properties. It is psychoactive, and leaves are chewed to uplift mood and to treat health problems. M. speciosa is indigenous to Thailand and, despite growing naturally in the country, has been outlawed for 70 years and was originally banned because it was reducing the Thai government's tax revenue from opium distribution. Kratom behaves as a μ-opioid receptor agonist like morphine and is used in the management of chronic pain, as well as recreationally. Kratom use is not detected by typical drug screening tests, but its metabolites can be detected by more specialized testing. The pharmacological effects of kratom on humans, including its efficacy and safety, are not well-studied. Most side effects of kratom are thought to be mild, although isolated serious adverse effects such as psychosis, convulsions, hallucinations, and confusion have been reported rarely.

Mitragyna speciosa

Medical use

Gallery

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Geografical distribution

  • ASIA-TROPICAL
    Native
    • Indo-China: Thailand
    • Malesia: Indonesia - Irian Jaya, Kalimantan, Sumatra; Malaysia; Papua New Guinea; Philippines - Luzon, Mindanao, Mindoro
    Cultivated
    • Indo-China: Vietnam

Biological activities

5-Lipoxygenase-Inhibitor
(-)-epicatechin found in Leaf (150 ppm)
ACE-Inhibitor
(-)-epicatechin found in Leaf (150 ppm)
Adrenolytic
Ajmalicine found in Leaf
Allelochemic
(-)-epicatechin found in Leaf (150 ppm)
Analgesic
Mitragynine found in Leaf (86 ppm)
Speciociliatine found in Leaf (30 ppm)
Anesthetic
Mitragynine found in Leaf (86 ppm)
Mitraphylline found in Leaf
Rhynchophylline found in Leaf
AntiEBV
(-)-epicatechin found in Leaf (150 ppm)
AntiHIV
(-)-epicatechin found in Leaf (150 ppm)
Antiadrenergic
Ajmalicine found in Leaf
Antiaggregant
(-)-epicatechin found in Leaf (150 ppm)
Ajmalicine found in Leaf
Rhynchophylline found in Leaf
Antianaphylactic
(-)-epicatechin found in Leaf (150 ppm)
Antibacterial
(-)-epicatechin found in Leaf (150 ppm)
Antidementia
Rhynchophylline found in Leaf
Antidiabetic
(-)-epicatechin found in Leaf (150 ppm)
Antidiuretic
Ajmalicine found in Leaf
Antiexcitotoxic
Rhynchophylline found in Leaf
Antihepatitic
(-)-epicatechin found in Leaf (150 ppm)
Antihyperglycemic
(-)-epicatechin found in Leaf (150 ppm)
Antihypertensive
Ajmalicine found in Leaf
Mitraphylline found in Leaf
Rhynchophylline found in Leaf
Antiinflammatory
(-)-epicatechin found in Leaf (150 ppm)
Antiischemic
Rhynchophylline found in Leaf
Antileukemic
(-)-epicatechin found in Leaf (150 ppm)
Isomitraphylline found in Leaf
Mitraphylline found in Leaf
Speciophylline found in Leaf
Antileukotriene
(-)-epicatechin found in Leaf (150 ppm)
Antilipoperoxidant
(-)-epicatechin found in Leaf (150 ppm)
Antimutagenic
(-)-epicatechin found in Leaf (150 ppm)
Antioxidant
(-)-epicatechin found in Leaf (150 ppm)
Rhynchophylline found in Leaf
Antiperoxidant
(-)-epicatechin found in Leaf (150 ppm)
Antipyretic
Rhynchophylline found in Leaf
Antiradicular
Rhynchophylline found in Leaf
Antithrombotic
Rhynchophylline found in Leaf
Antitussive
Speciociliatine found in Leaf (30 ppm)
Antiviral
(-)-epicatechin found in Leaf (150 ppm)
CNS-Depressant
Ajmalicine found in Leaf
Mitraphylline found in Leaf
CNS-Stimulant
Mitragynine found in Leaf (86 ppm)
COMP-Inhibitor
(-)-epicatechin found in Leaf (150 ppm)
Calcium-Antagonist
Rhynchophylline found in Leaf
Calcium-Blocker
Rhynchophylline found in Leaf
Cancer-Preventive
(-)-epicatechin found in Leaf (150 ppm)
Cardiodepressant
Mitraphylline found in Leaf
Rhynchophylline found in Leaf
Cardiotonic
(-)-epicatechin found in Leaf (150 ppm)
Cerebrocirculant
Ajmalicine found in Leaf
Choline-Sparing
(-)-epicatechin found in Leaf (150 ppm)
Circulotonic
Ajmalicine found in Leaf
Cytotoxic
(-)-epicatechin found in Leaf (150 ppm)
Uncarine-d found in Plant
Dopaminergic
Rhynchophylline found in Leaf
Febrifuge
Rhynchophylline found in Leaf
Hypocholesterolemic
(-)-epicatechin found in Leaf (150 ppm)
Hypoglycemic
(-)-epicatechin found in Leaf (150 ppm)
Hypotensive
Ajmalicine found in Leaf
Mitragynine found in Leaf (86 ppm)
Mitraphylline found in Leaf
Rhynchophylline found in Leaf
Immunostimulant
(-)-epicatechin found in Leaf (150 ppm)
Isomitraphylline found in Leaf
Mitraphylline found in Leaf
Insulinogenic
(-)-epicatechin found in Leaf (150 ppm)
Lipoxygenase-1-Inhibitor
(-)-epicatechin found in Leaf (150 ppm)
Lipoxygenase-Inhibitor
(-)-epicatechin found in Leaf (150 ppm)
Myocontractant
Mitraphylline found in Leaf
Rhynchophylline found in Leaf
Myorelaxant
Mitragynine found in Leaf (86 ppm)
Mitraphylline found in Leaf
Neuroparalytic
Rhynchophylline found in Leaf
Pancreatogenic
(-)-epicatechin found in Leaf (150 ppm)
Pesticide
(-)-epicatechin found in Leaf (150 ppm)
Mitraphylline found in Leaf
Phagocytotic
Isomitraphylline found in Leaf
Protisticide
Mitraphylline found in Leaf
Rhynchophylline found in Leaf
Reverse-Transcriptase-Inhibitor
(-)-epicatechin found in Leaf (150 ppm)
Sedative
Rhynchophylline found in Leaf
Serotonergic
Rhynchophylline found in Leaf
Sympatholytic
Ajmalicine found in Leaf
Tranquilizer
Ajmalicine found in Leaf
Uterotonic
Rhynchophylline found in Leaf
Vasodilator
(-)-epicatechin found in Leaf (150 ppm)
Mitragynine found in Leaf (86 ppm)
Mitraphylline found in Leaf
Rhynchophylline found in Leaf
Xanthine-Oxidase-Inhibitor
(-)-epicatechin found in Leaf (150 ppm)

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Chemicals detected

Reference: Dr. Duke's Phytochemical and Ethnobotanical Databases. [Online Database]