Topoisomerase-I-Inhibitor biological activity

List of chemicals and dosages (if available) with Topoisomerase-I-Inhibitor biological activity
10-hydroxycamptothecin 0.4-1 uM
17-beta-estradiol
Acacetin
Amarogentin 5 uM
Apigenin
Beta-lapachone
Biochanin-a
Bis-demethoxycurcumin
Caffeine 0.1 nM75 uM
Camptothecin 1-50 uMED50=0.8 uMIC50=1 uMIC50=670 nM
Chebulagic-acid IC50=50 nM
Chebulanin
Chelerythrine
Chrysin
Corilagin IC50=40 uM
Curcumin
Daidzein
Demethoxycurcumin
Epiberberine 250 uM
Fisetin IC50=20.6 ug/ml
Formononetin
Galangin
Gallic-acid
Genistein 1-10 ug/mlIC50=250 ppm
Harman ED50=23.8 ug/ml (weak)
Kaempferide
Kaempferol
Luteolin
Morin IC50=42.1 ug/ml (weak activity)
Myricetin IC50=11.9 ug/ml
Naringenin
Nitidine 0.15 uM
Norharman ED50=34.4 ug/ml (weak activity)
Pedunculagin
Quercetin IC50=12.8 ug/mlIC50=42 uM
Sanguiin-h-6 IC50=0.02-5 uM
Velutin