Zanthoxylum clava-herculis Health effects and herbal facts

Zanthoxylum clava-herculis, Hercules' club, pepperwood, or southern prickly ash, is a spiny tree or shrub native to the southeastern United States. It grows to 10–17 m tall and has distinctive spined thick, corky lumps 2–3 cm long on the bark. The leaves are glabrous and leathery, pinnately compound, 20–30 cm long with 7-19 leaflets, each leaflet 4–5 cm long. The flowers are dioecious, in panicles up to 20 cm long, each flower small, 6–8 mm diameter, with 3-5 white petals. The fruit is a two-valved capsule 6 mm diameter with a rough surface, and containing several small black seeds. The tree has also been called Z. macrophyllum. The genus name is sometimes spelled Xanthoxylum. Along with the related Zanthoxylum americanum, it is sometimes called "toothache tree" or "tingle tongue" because of the numbness of the mouth, teeth, and tongue induced by chewing on its leaves or bark. It was used for such medicinal purposes by both Native Americans and early settlers. The tree has a rounded crown and requires plentiful water and sunlight. Its leaves are browsed by deer and its fruit is eaten by birds. The fruit passes through birds, which helps the seeds to germinate.

Zanthoxylum clava-herculis

Medical use

Gallery

Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis Zanthoxylum clava-herculis

Biological activities

12-Lipoxygenase-Inhibitor
Chelerythrine found in Bark
5-Lipoxygenase-Inhibitor
Chelerythrine found in Bark
Abortifacient
Berberine found in Bark ;found in Plant
Adrenolytic
Berberine found in Bark ;found in Plant
Allergenic
Sesamin found in Bark
Amebicide
Berberine found in Bark ;found in Plant
Analgesic
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Anesthetic
Berberine found in Bark ;found in Plant
Antiacetylcholinesterase
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Antiacne
Berberine found in Bark ;found in Plant
Antiadrenergic
Berberine found in Bark ;found in Plant
Antiaggregant
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Antialzheimeran
Berberine found in Bark ;found in Plant
Antiamnesic
Berberine found in Bark ;found in Plant
Antiangiogenic
Berberine found in Bark ;found in Plant
Antiarrhythmic
Berberine found in Bark ;found in Plant
Antiarthritic
Berberine found in Bark ;found in Plant
Antibacillus
Berberine found in Bark ;found in Plant
Antibacterial
Asarinin found in Bark
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Magnoflorine found in Plant ;found in Root Bark
Sesamin found in Bark
Antibiotic
Berberine found in Bark ;found in Plant
Anticancer
Berberine found in Bark ;found in Plant
Anticariogenic
Berberine found in Bark ;found in Plant
Antichlamydial
Berberine found in Bark ;found in Plant
Anticholecystitic
Berberine found in Bark ;found in Plant
Anticholera
Berberine found in Bark ;found in Plant
Anticirrhotic
Berberine found in Bark ;found in Plant
Anticonjunctivitic
Berberine found in Bark ;found in Plant
Anticonvulsant
Berberine found in Bark ;found in Plant
Antidiarrheic
Berberine found in Bark ;found in Plant
Antidysenteric
Berberine found in Bark ;found in Plant
Antiedemic
Berberine found in Bark ;found in Plant
Antiendotoxic
Berberine found in Bark ;found in Plant
Antienterotoxic
Berberine found in Bark ;found in Plant
Antiesherichic
Berberine found in Bark ;found in Plant
Antigiardial
Berberine found in Bark ;found in Plant
Antiglaucomic
Berberine found in Bark ;found in Plant
Antigonorrhea
Berberine found in Bark ;found in Plant
Antihepatomic
Berberine found in Bark ;found in Plant
Antihepatotic
Berberine found in Bark ;found in Plant
Antiherpetic
Berberine found in Bark ;found in Plant
Antihistaminic
Berberine found in Bark ;found in Plant
Antiinflammatory
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Antiischemic
Berberine found in Bark ;found in Plant
Antileishmanic
Berberine found in Bark ;found in Plant
Antileukemic
Asarinin found in Bark
Nitidine found in Bark ;found in Plant
Sesamin found in Bark
Antilipogenic
Berberine found in Bark ;found in Plant
Antimalarial
Berberine found in Bark ;found in Plant
Antimitotic
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Antimuscarinic
Berberine found in Bark ;found in Plant
Antimyalgic
Berberine found in Bark ;found in Plant
Antimycotic
Berberine found in Bark ;found in Plant
Antineoplastic
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Antinephritic
Berberine found in Bark ;found in Plant
Antineuromuscular
Magnoflorine found in Plant ;found in Root Bark
Antioxidant
Myristic-acid found in Bark
Sesamin found in Bark
Antiperistaltic
Berberine found in Bark ;found in Plant
Antipharyngitic
Berberine found in Bark ;found in Plant
Antiphotooxidative
Berberine found in Bark ;found in Plant
Antiplasmodial
Berberine found in Bark ;found in Plant
Antipneumonic
Berberine found in Bark ;found in Plant
Antipyretic
Berberine found in Bark ;found in Plant
Antisalmonella
Berberine found in Bark ;found in Plant
Antisecretory
Berberine found in Bark ;found in Plant
Antiseptic
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Antishigellic
Berberine found in Bark ;found in Plant
Antispasmodic
Berberine found in Bark ;found in Plant
Magnoflorine found in Plant ;found in Root Bark
Antispermigenic
Berberine found in Bark ;found in Plant
Antistaphylococcic
Berberine found in Bark ;found in Plant
Antistrep
Berberine found in Bark ;found in Plant
Antisyphilitic
Berberine found in Bark ;found in Plant
Antitrachomic
Berberine found in Bark ;found in Plant
Antitrypanosomic
Berberine found in Bark ;found in Plant
Antitubercular
Asarinin found in Bark
Berberine found in Bark ;found in Plant
Antitumor
Chelerythrine found in Bark
Nitidine found in Bark ;found in Plant
Antitussive
Chelerythrine found in Bark
Antiulcer
Berberine found in Bark ;found in Plant
Antivaginitic
Berberine found in Bark ;found in Plant
Antiviral
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Astringent
Berberine found in Bark ;found in Plant
Bilirubinolytic
Berberine found in Bark ;found in Plant
CNS-Depressant
Magnoflorine found in Plant ;found in Root Bark
COX-2-Inhibitor
Berberine found in Bark ;found in Plant
Calcium-Antagonist
Berberine found in Bark ;found in Plant
Cancer-Preventive
Myristic-acid found in Bark
Candidicide
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Cardiodepressant
Berberine found in Bark ;found in Plant
Cardiotonic
Berberine found in Bark ;found in Plant
Carminative
Berberine found in Bark ;found in Plant
Cholagogue
Berberine found in Bark ;found in Plant
Cholekinetic
Berberine found in Bark ;found in Plant
Choleretic
Berberine found in Bark ;found in Plant
Collyrium
Berberine found in Bark ;found in Plant
Cosmetic
Myristic-acid found in Bark
Curare
Candicine found in Bark ;found in Root Bark
Curaroid
Magnoflorine found in Plant ;found in Root Bark
Cyclooxygenase-Inhibitor
Berberine found in Bark ;found in Plant
Cytostatic
Sesamin found in Bark
Cytotoxic
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
DNA-Intercalator
Chelerythrine found in Bark
Desaturase-Inhibitor
Sesamin found in Bark
Digestive
Berberine found in Bark ;found in Plant
Diuretic
Berberine found in Bark ;found in Plant
Emetic
Berberine found in Bark ;found in Plant
Epileptigenic
Candicine found in Bark ;found in Root Bark
Fungicide
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Glaucomagenic
Berberine found in Bark ;found in Plant
Hemostat
Berberine found in Bark ;found in Plant
Hepatoprotective
Sesamin found in Bark
Hypercholesterolemic
Myristic-acid found in Bark
Hypertensive
Candicine found in Bark ;found in Root Bark
Chelerythrine found in Bark
Hypocholesterolemic
Berberine found in Bark ;found in Plant
Sesamin found in Bark
Hypoglycemic
Berberine found in Bark ;found in Plant
Hypotensive
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Magnoflorine found in Plant ;found in Root Bark
Immunostimulant
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Immunosuppressant
Sesamin found in Bark
Insecticide-Synergist
Asarinin found in Bark
Sesamin found in Bark
Insecticide
Herculin found in Bark
Irritant
Chelerythrine found in Bark
Juvabional
Sesamin found in Bark
Lachrymatory
Berberine found in Bark ;found in Plant
Larvicide
Berberine found in Bark ;found in Plant
Leucocytogenic
Berberine found in Bark ;found in Plant
Lipase-Inhibitor
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Lipoxygenase-Inhibitor
Berberine found in Bark ;found in Plant
Lubricant
Myristic-acid found in Bark
Molluscicide
Chelerythrine found in Bark
Mutagenic
Berberine found in Bark ;found in Plant
Mycobactericide
Berberine found in Bark ;found in Plant
Mydriatic
Berberine found in Bark ;found in Plant
Myocardiodepressant
Berberine found in Bark ;found in Plant
Myorelaxant
Berberine found in Bark ;found in Plant
Nematicide
Chelerythrine found in Bark
Myristic-acid found in Bark
Nicotinic
Candicine found in Bark ;found in Root Bark
Occulotensive
Chelerythrine found in Bark
PAF-Inhibitor
Magnoflorine found in Plant ;found in Root Bark
Paralytic
Chelerythrine found in Bark
Magnoflorine found in Plant ;found in Root Bark
Pesticide
Asarinin found in Bark
Berberine found in Bark ;found in Plant
Chelerythrine found in Bark
Herculin found in Bark
Magnoflorine found in Plant ;found in Root Bark
N-acetylanonaine found in Bark
Neoherculin found in Bark
Sesamin found in Bark
Phototoxic
Berberine found in Bark ;found in Plant
Piscicide
Asarinin found in Bark
N-acetylanonaine found in Bark
Neoherculin found in Bark
Sesamin found in Bark
Plasmodicide
Berberine found in Bark ;found in Plant
Prostaglandin-Synthesis-Inhibitor
Berberine found in Bark ;found in Plant
Protisticide
Berberine found in Bark ;found in Plant
RNA-Depressant
Berberine found in Bark ;found in Plant
RT-Inhibitor
Berberine found in Bark ;found in Plant
Respiradepressant
Berberine found in Bark ;found in Plant
Respirainhibitor
Chelerythrine found in Bark
Reverse-Transcriptase-Inhibitor
Nitidine found in Bark ;found in Plant
Sedative
Berberine found in Bark ;found in Plant
Sialogogue
Neoherculin found in Bark
Stomachic
Berberine found in Bark ;found in Plant
Tetanic
Chelerythrine found in Bark
Tocopherol-Synergist
Sesamin found in Bark
Topoisomerase-I-Inhibitor
Chelerythrine found in Bark
Nitidine found in Bark ;found in Plant
Topoisomerase-II-Inhibitor
Berberine found in Bark ;found in Plant
Nitidine found in Bark ;found in Plant
Toxic
Magnoflorine found in Plant ;found in Root Bark
Trichomonicide
Berberine found in Bark ;found in Plant
Trypanocide
Berberine found in Bark ;found in Plant
Uterocontractant
Berberine found in Bark ;found in Plant
Uterotonic
Berberine found in Bark ;found in Plant
Vagostimulant
Berberine found in Bark ;found in Plant
Vasoconstrictor
Berberine found in Bark ;found in Plant
Vasodilator
Berberine found in Bark ;found in Plant
Magnoflorine found in Plant ;found in Root Bark
Vermifuge
Berberine found in Bark ;found in Plant
Vibriofuge
Berberine found in Bark ;found in Plant

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Chemicals detected

Chemical Plant part Low ppm High ppm
(+)-laurifoline Root Bark
(-)-asarinin Bark
(-)-pluviatilol-gamma-gamma-dimethyl-allyl-ether Bark
(-)-sesamin Bark
6-o-methyltyramine-n-methyl-cinnamide Bark
Asarinin Bark
Berberine Bark
Plant
Candicine Bark
Root Bark
Chelerythrine Bark
Cinnamamide Bark
Eo Plant 33,000
Herclavin Bark
Herclavine Bark
Herculin Bark
Isobutyl-amide Bark
Laurifoline Plant
Magnoflorine Plant
Root Bark
Myristic-acid Bark
N-acetylanonaine Bark
Neoherculin Bark
Neoherculine Bark
Nitidine Bark
Plant
Phytosterol Bark
Pluviatilol-gamma-gamma-dimethyl-allyl-ether Bark
Resins Bark
Sesamin Bark
Tannins Plant
Tembetarine Bark
Root Bark
Xanthoxylin-s Bark
Reference: Dr. Duke's Phytochemical and Ethnobotanical Databases. [Online Database]